SCALP & HAIR
Primary Focus
- Scalp-focused cosmetic treatment
- Supports a healthier-looking scalp
- Supports the look of fuller, thicker-looking hair
- Popular with clients concerned about the look of thinning hair
Day-0 Perinatal Exosomes · AlphaCore
Perinatal Exosome Hair & Skin Treatment
Day-0 Perinatal Exosomes with GHK-Cu peptide booster to support the look of a healthier scalp and refreshed skin.
What Are Day-0 Perinatal Exosomes?
Exosomes are tiny membrane-bound vesicles, roughly 30–150 nanometers across, that cells release to communicate with one another. Each one carries proteins, lipids and genetic messengers such as microRNA. AlphaCore uses a cell-free, perinatal-derived exosome preparation applied topically after microneedling. It contains no living cells and is never injected.
Acellular means cell-free: no living cells, only what cells release.
Stem Cells vs. Secretome vs. Exosomes — They're Not the Same
Think of a stem cell as a factory. The secretome is everything the factory ships out. Exosomes are the sealed packages inside that shipment.
Living cells
Stem Cells (MSCs)
Mesenchymal stem/stromal cells are living cells, typically sourced from bone marrow, fat, umbilical cord or placenta. They are the source that produces signals. Living-cell therapies are tightly regulated by the FDA, and none are approved for cosmetic use.
AlphaCore does not use stem cells.
Everything a cell releases
Secretome
The full collection of what cells secrete: growth factors, cytokines, other proteins, lipids, and extracellular vesicles, including exosomes. Often sold as 'conditioned media.' Cell-free, but a broad, mixed cocktail.
What we use
One part of the secretome
Exosomes
A specific type of extracellular vesicle, 30–150 nm, with a protective membrane carrying proteins, lipids and RNA between cells. Cell-free, and a narrower, more specific component than the full secretome.
Bottom line: exosomes come from cells, are part of the secretome, and are not stem cells.
Side-by-Side: An Educational Example
| Attribute | Stem Cells (MSCs) | Secretome | Exosomes |
|---|---|---|---|
| What it is | A living cell | Everything a cell releases | One type of vesicle a cell releases |
| Living cells? | Yes | No | No |
| Approximate size | ~15–30 micrometers (a whole cell) | Mixed: individual proteins plus vesicles | ~30–150 nanometers |
| How it's typically made | Collected from tissue and grown in a lab | Liquid collected from cells grown in a lab ("conditioned media") | Isolated and concentrated from that liquid |
| FDA status | One MSC product is FDA-approved, for a serious pediatric transplant complication; none for cosmetic use | No FDA-approved products | No FDA-approved products |
To picture the size difference: if one exosome were the size of a marble, a single stem cell would be roughly the height of a person — about 200 times larger.
For educational purposes only. This information is not medical advice and is not intended to diagnose, treat, cure or prevent any disease or condition. Treatments at AlphaCore are cosmetic, and candidacy is determined at your consultation. Talk with a qualified provider about your individual needs.
Why PRP and PRF Results Can Vary
Your blood, your baseline. PRP (platelet-rich plasma) and PRF (platelet-rich fibrin) are made from your own blood. That means what goes into the treatment reflects you at that moment: your age, sex, body weight and overall health.
Research shows the makeup of PRP varies widely from person to person. In one study, older adults had lower levels of IGF-1, a growth factor, and a less favorable balance of growth factors to inflammatory signals than younger adults. Body weight and sex also changed PRP composition.
What this can mean for you: if your system is under strain from age, ongoing inflammation or other health factors, your own platelets may bring that same baseline into the treatment. That's one reason results with PRP and PRF can be less predictable from one person to the next.
Perinatal vs. Bone Marrow and Fat-Derived Exosomes
Where exosomes come from matters. Many exosome products are made from cells taken from adult bone marrow or fat. Those cells have aged along with the donor.
Early laboratory research suggests donor age may change what cells release. In one study, exosomes from older donors' bone marrow cells carried less total genetic cargo (microRNA) than those from younger donors, and behaved differently in lab tests. Another lab study found that vesicles from younger donors' cells shifted older cells toward a younger profile, while vesicles from older donors did the reverse.
Perinatal sources are collected from birth tissue at delivery, the youngest available source.
This research is early and mostly done in the lab. No head-to-head clinical studies prove one exosome source gives better cosmetic results than another.
| Attribute | PRP / PRF | Adult-derived exosomes (bone marrow, fat) | Perinatal exosomes |
|---|---|---|---|
| Source | Your own blood | Adult donor cells | Birth tissue collected at delivery |
| Depends on your age and health? | Yes | No, but on the donor's age | No |
| Living cells? | No (platelets, not cells) | No | No |
| Donor age | Your age | Adult, often older | Newborn tissue |
For educational purposes only. This information is not medical advice and is not intended to diagnose, treat, cure or prevent any disease or condition. Individual results vary. Talk with a qualified provider about your individual needs.
Sources
- Physiological factors affecting PRP variability, Frontiers in Veterinary Science, 2025
- Men and Women Differ in the Biochemical Composition of PRP, American Journal of Sports Medicine, 2018
- MSC-derived EVs modulate stem cells in an age-dependent manner, Frontiers in Bioengineering and Biotechnology, 2022
- MSC-derived extracellular vesicles and their role in ageing, Stem Cell Research & Therapy, 2020
Why Day-0 Matters
Most clinics offer adult-tissue exosomes derived from bone marrow or fat (adipose) tissue. These sources carry accumulated cellular stress, environmental wear, and signs of aging.
Perinatal sources come from young birth tissue collected at delivery, while adult sources come from tissue that has aged along with the donor. Microneedling and GHK-Cu prepare the skin; the exosome preparation is applied to support the skin's natural renewal. The manufacturer specifies approximately 30 billion exosome particles per vial.
Hair & Skin Applications
SKIN RENEWAL
Secondary Focus
- Supports smoother, firmer-looking skin
- Supports the look of skin texture and elasticity
- Added comfort after microneedling
- Minimal downtime
Ethical Sourcing & Safety
Ethically Sourced
Gathered from healthy, consenting mothers following pre-scheduled full-term C-section deliveries, per the manufacturer.
Comprehensive Donor Screening
Every donor undergoes thorough health history and serological screening, per the manufacturer.
cGMP Certified Cleanrooms
Prepared in cGMP cleanrooms following American Association of Tissue Banks (AATB) guidelines, per the manufacturer.
Third-Party Sterility Testing
Every batch undergoes independent sterility and endotoxin testing.
30 Billion Particles per Vial
Approximately 30 billion exosome particles per vial, per the manufacturer's specification.
Minimal Downtime
Mild redness typically settles within 24–48 hours; many clients return to normal activity the next day. Individual experiences vary.
Investment
Single Session · $950
- One treatment session
- Day-0 Perinatal Exosome protocol
- GHK-Cu peptide booster
- Combined with microneedling
- Best for: trying the service or occasional maintenance
3-Session Transformation Package · $2,350
BEST VALUE- Three treatment sessions
- Save $400 vs single sessions
- One session per month for 3 months
- Best for: patients wanting real, sustained results
You Deserve to Know What's in the Vial
The words "stem cells," "exosomes" and "secretome" are often used loosely, and the details aren't always explained. Before any exosome or "stem cell" treatment, ask:
- Is it living cells, secretome or exosomes?
- Where does it come from, and how old was the donor?
- Is it FDA-approved? (Right now, none are.)
- What does the research actually show?
If your provider can't answer, keep asking. We'll always walk you through it.
Your Treatment Journey
STEP 1
Free Discovery Call
15-minute discovery call to make sure you're a candidate.
STEP 2
Clinical Evaluation
Full clinical assessment to confirm candidacy before your first treatment.
STEP 3
Treatment Session
Numbing cream first. Microneedling followed by topical Day-0 exosome application with GHK-Cu booster. 60-90 minutes.
STEP 4
Downtime & Follow-Up
Mild redness 24-48 hours. Photo tracking to document your response over time.
Questions, Answered
Ready to Learn More?
Book a free discovery call to see if Day-0 Perinatal Exosome therapy is right for you.
Questions? Call Marie: (484) 275-0573
Perinatal Exosome Hair & Skin Treatments used at AlphaCore Health are intended for topical use only and are non-injectable. They are not FDA-approved drugs and are not intended to diagnose, treat, cure, or prevent any disease. Individual results vary. Purchasing this service does not guarantee any specific outcome. Candidacy is determined by clinical evaluation. AlphaCore Health is a cash-pay practice.